To start using EndNote, you need to create a library to store your references.
*Note: You may select a folder on the local drive of your computer to save the EndNote library. However, do not save the EndNote library to any USB drive, network drive/shared server, cloud-syncing folder, or cloud drive. This will lead to a EndNote library damage. For more information, refer to EndNote: Few reasons why the library may get damaged frequently.
Tip: EndNote works more reliably if you create one 'master' library of references and use the Groups feature to keep your references organized.